Nonoccupational postexposure prophylaxis (nPEP) for HIV

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The CDC recently released updated guidelines for the use of antiretroviral postexposure prophylaxis after sexual contact, injection drug use, and other nonoccupational exposures to HIV. Nonoccupational postexposure prophylaxis (nPEP) is recommended only for HIV-negative persons who present within 72 hours after an exposure that has a substantial risk for HIV transmission. The preferred antiretroviral regimen for nPEP in adult and adolescent patients aged >13 years is tenofovir disoproxil fumarate/emtricitabine (Truvada) plus either raltegravir or dolutegravir. Renal function and other patient-specific factors that require alternative regimens are also included in these guidelines. Pharmacists are in a key position to work with healthcare providers to select the most appropriate nPEP regimen.

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