Dr. Jamey Maniscalco
Dr. Brian Drwecki
Thesis - Open Access
Number of Pages
The typical ‘Western Diet’ includes a diet high in fats and sugars. This thesis explores the problems that this type of diet could have on the brain. A meta-analysis was conducted to show activated microglia count in the hypothalamus of mice after a high-fat diet. The results showed a large effect size with the included studies, showing that a high fat diet significantly increases microglia count across studies. Increased activated microglia leads to chronic inflammation in the hypothalamus, which is linked to metabolic problems like insulin resistance, leptin resistance and glucose intolerance.
Date of Award
© Emily Karabeika
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Karabeika, Emily, "The Effects of a High-Fat Diet on the Brain; A Meta-Analysis of Microglia in the Hypothalamus" (2020). Regis University Student Publications (comprehensive collection). 951.