Regis College Senior Honors Program
Thesis - Open Access
Number of Pages
The neurological pathways for posttraumatic stress disorder have come under scrutiny in recent years due to emerging research on the endocannabinoid system. Suggested involvement in the fear and stress pathways involve the pre-synaptic modulation of corticosteroid activity upon the consolidation and extinction of emotional memories in the hippocampus or the basolateral amygdala or possibly the GABA, 5-HT, and NE neuronal projections that are centered in the medial pre-frontal cortex that have been implicated in the hyperarousal and negative affect of PTSD. This study will focus on the use of anandamide, a CB1 and CB2 agonist in the treatment of PTSD behavioral symptoms of a rat model, specifically general anxiety, avoidance, generalization, and spatial learning and memory.
Date of Award
© Zachery Koneval
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Koneval, Zachery, "The Effects of Anandamide, a Cb1 and Cb2 Agonist, on the Behaviior and Neurochemisty on a Rat Model of Post-Traumatic Stress Disorder" (2016). Regis University Student Publications. 709.