First Advisor

Basham, Mark


Dimos, Johnathan


Regis College

Degree Name



Regis College Senior Honors Program

Document Type

Thesis - Open Access



Number of Pages

50 pages


The neurological pathways for posttraumatic stress disorder have come under scrutiny in recent years due to emerging research on the endocannabinoid system. Suggested involvement in the fear and stress pathways involve the pre-synaptic modulation of corticosteroid activity upon the consolidation and extinction of emotional memories in the hippocampus or the basolateral amygdala or possibly the GABA, 5-HT, and NE neuronal projections that are centered in the medial pre-frontal cortex that have been implicated in the hyperarousal and negative affect of PTSD. This study will focus on the use of anandamide, a CB1 and CB2 agonist in the treatment of PTSD behavioral symptoms of a rat model, specifically general anxiety, avoidance, generalization, and spatial learning and memory.

Date of Award

Spring 2016

Location (Creation)

Colorado (state); Denver (county); Denver (inhabited place)

Rights Statement

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