Regis College Senior Honors Program
Thesis - Open Access
Number of Pages
The atypical antipsychotic clozapine improves spatial memory in rats with partial hippocampal lesions. However, the effectiveness of treatment with clozapine before brain injury is unknown. To assess the possibility that chronic pretreatment with clozapine might preserve spatial memory after a hippocampal lesion, we injected rats with either saline or clozapine for one month prior to partial hippocampal lesioning and then assessed spatial learning. Our initial results suggest that pretreatment with clozapine might minimize spatial memory deficits following partial hippocampal lesions. This finding has implications for the prevention and treatment of spatial memory deficits.
Date of Award
© Justin Losacco
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Losacco, Justin T., "Effects of Pretreatment with Clozapine On Spatial Memory of Rats with Lesioned Dorsal Hippocampi" (2010). Student Publications. 539.