First Advisor

Bowie, Thomas


Regis College

Degree Name



Regis College Senior Honors Program

Document Type

Thesis - Open Access

Number of Pages

22 pages


The atypical antipsychotic clozapine improves spatial memory in rats with partial hippocampal lesions. However, the effectiveness of treatment with clozapine before brain injury is unknown. To assess the possibility that chronic pretreatment with clozapine might preserve spatial memory after a hippocampal lesion, we injected rats with either saline or clozapine for one month prior to partial hippocampal lesioning and then assessed spatial learning. Our initial results suggest that pretreatment with clozapine might minimize spatial memory deficits following partial hippocampal lesions. This finding has implications for the prevention and treatment of spatial memory deficits.

Date of Award

Spring 2010

Location (Creation)

Denver, Colorado

Rights Statement

All content in this Collection is owned by and subject to the exclusive control of Regis University and the authors of the materials. It is available only for research purposes and may not be used in violation of copyright laws or for unlawful purposes. The materials may not be downloaded in whole or in part without permission of the copyright holder or as otherwise authorized in the “fair use” standards of the U.S. copyright laws and regulations.