First Advisor

Ernst, Diane

Thesis Committee Member(s)

Finn, Cris


Rueckert-Hartman College for Health Professions

Degree Name

Doctor of Nursing Practice


Loretto Heights School of Nursing

Document Type

Thesis - Open Access

Number of Pages

156 pages


Multiple myeloma is the second leading cause of hematological malignancies in the United States. Bortezomib is a chemotherapy agent effective in the treatment of all stages of multiple myeloma. Bortezomib administered by the subcutaneous (SC) route is as efficacious as the intravenous (IV) route. However, the literature does not describe how the drug was to be administered SC. A review of literature was inconclusive on how to administer SC injections and supported the need to describe how nurses are administering SC injections in order to develop practice guidelines. A 44-question electronic survey on SC bortezomib administration was developed, with all questions based on current literature regarding appropriate techniques for administering SC injections. The questions explored site of administration, needle length, angle of insertion, use of air purge or bubble technique, and duration of administration. Questions were also included regarding convenience of SC administration, nurses' opinions on patients' preferences for administration site, and opinions about adopting standard practice guidelines. The findings indicated different techniques were being used for SC bortezomib administration. A practice guideline was developed for implementation with the aim of achieving greater consistency among oncology nurses administering SC bortezomib within the community oncology network of clinics.

Date of Award

Fall 2013

Location (Creation)

Colorado (state); Denver (county); Denver (inhabited place)

Rights Statement

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