Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications
Post-translational protein modifications are a dynamic method of regulating protein function in response to environmental signals. As with any cellular process, T cell receptor (TCR) complex-mediated signaling is highly regulated, since the strength and duration of TCR-generated signals governs T cell development and activation. While regulation of TCR complex-mediated signaling by phosphorylation has been well studied, regulation by ubiquitin and ubiquitin-like modifiers is still an emerging area of investigation. This review will examine how ubiquitin, E3 ubiquitin ligases, and other ubiquitin-like modifications such as SUMO and NEDD8 regulate TCR complex-mediated signaling.
Friend, Samantha F.; Deason-Towne, Francina; Peterson, Lisa K.; Berger, Allison J.; and Dragone, Leonard L., "Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications" (2014). Regis University Faculty Publications. 620.