First Advisor

Basham, Mark

Reader

Dimos, Johnathan

College

Regis College

Degree Name

BS

School

Regis College Senior Honors Program

Document Type

Thesis - Open Access

Comments

Neuroscience

Number of Pages

50 pages

Abstract

The neurological pathways for posttraumatic stress disorder have come under scrutiny in recent years due to emerging research on the endocannabinoid system. Suggested involvement in the fear and stress pathways involve the pre-synaptic modulation of corticosteroid activity upon the consolidation and extinction of emotional memories in the hippocampus or the basolateral amygdala or possibly the GABA, 5-HT, and NE neuronal projections that are centered in the medial pre-frontal cortex that have been implicated in the hyperarousal and negative affect of PTSD. This study will focus on the use of anandamide, a CB1 and CB2 agonist in the treatment of PTSD behavioral symptoms of a rat model, specifically general anxiety, avoidance, generalization, and spatial learning and memory.

Date of Award

Spring 2016

Location (Creation)

Colorado (state); Denver (county); Denver (inhabited place)

Rights Statement

All content in this Collection is owned by and subject to the exclusive control of Regis University and the authors of the materials. It is available only for research purposes and may not be used in violation of copyright laws or for unlawful purposes. The materials may not be downloaded in whole or in part without permission of the copyright holder or as otherwise authorized in the “fair use” standards of the U.S. copyright laws and regulations.

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